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publications
L-Asparaginase: Challenges and Development of Next Generation ASNase Therapeutic Molecule
Published in Emerging Concepts in Chemical and Biological Sciences (Book), 2020
To conduct and compile a comprehensive literature survey on the extensive investigation of L-asparaginase as an anticancer agent, highlighting its therapeutic potential and associated limitations.
Biohydrogen production from anaerobic sewage sludge
Published in Development in Waste Water Treatment Research and Processes (Book), 2020
The goal of this book chapter was to explore and highlight various techniques for producing bioenergy in the form of biohydrogen gas using sewage sludge, an abundantly available waste resource.
Molecular Docking Based in-Silico Approach Reveals the Potential Inhibitory Activity of NSAIDs against Sars-Cov-2 Proteins
Published in International Journal of Pharmaceutical Sciences and Research, 2023
To develop a library of non-steroidal anti-inflammatory drugs (NSAIDs) and evaluate their potential to retain potency against mutated strains of the SARS-CoV-2 virus.
Cellular, Biophysical and in Silico Binding Study of β-Estradiol-6-one 6-(O-carboxy methyl Oxime) with Tubulin in Search of Antimitotic Derivative of 2-Methoxy Estradiol
Published in Cell Biochemistry and Biophysics, 2023
To address the severe side effects of colchicine, a potent tubulin-destabilizing anti-cancer drug, by identifying alternative compounds with similar pharmacophores.
Conjugation and encapsulation of L-asparaginase: an effective strategy for augmenting enzyme potential for anticancer activity
Published in Food Science and Applied Biotechnology, 2023
This review article aimed to survey the available strategies for encapsulating L-asparaginase to mitigate its side effects and enhance its efficacy as an anticancer agent, ultimately presenting a comprehensive analysis of the literature.
talks
Talk 1 on Relevant Topic in Your Field
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Conference Proceeding talk 3 on Relevant Topic in Your Field
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teaching
Anti-Mitotic Activity of NSAIDs: Molecular Target Identification
Dept. of Biophysics, MolecularBiology and Bioinformatics, University of Calcutta and Haldia Institute of Technology, 2019
Goal
To evaluate the anti-mitotic activity of Diclofenac and its effect on the identified target, Lactate Dehydrogenase-A (LDH-A).
Combining Snail-mediated EMT targeting with chemotherapy as a potential treatment strategy for prostate and breast cancer
Dept. of Biosciences and Bioengineering, IIT Kanpur, 2024
Goal
To identify a biomolecule at the intersection of epithelial-to-mesenchymal transition (EMT), metastasis, and chemoresistance, and develop a therapeutic strategy by targeting the biomolecule using a small molecule drug in combination with chemotherapy.
Targeting cancer cells and cancer-associated fibroblasts in breast cancer using podoplanin targeting nanoparticle mediated delivery of combined chemotherapeutic and anti-fibrotic treatment
Dept. of Biosciences and Bioengineering, IIT Kanpur, India, 2024
Goal
To develop a drug delivery-assisted combination therapy targeting both cancer-associated fibroblasts (CAFs) and cancer cells.